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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDmethylmercuric chloride results in decreased activity of CAT proteinPMID:19468715 PMID:22269903 PMID:29258870 PMID:31330227
Catdecreases expressionEXP 6480464CTDmethylmercuric chloride results in decreased expression of CAT proteinPMID:34062221
Catmultiple interactionsEXP 6480464CTDalpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Bee Venoms inhibits the reaction [methylmercuric chloride results in decreased expression of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; eleostearic acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]PMID:22269903 PMID:31330227 PMID:34062221
Catincreases expressionISOCat (Mus musculus)6480464CTDmethylmercuric chloride results in increased expression of CAT mRNAPMID:20061341
Catmultiple interactionsISOCat (Mus musculus)6480464CTD[[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of CAT protein; [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CAT proteinPMID:32179164
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