Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDMelatonin results in decreased activity of CAT proteinPMID:12823611
Catincreases expressionEXP 6480464CTDMelatonin results in increased expression of CAT mRNAPMID:15589378 PMID:16098089
Catmultiple interactionsEXP 6480464CTD[aluminum lactate co-treated with Melatonin] results in increased activity of CAT mRNA; [aluminum lactate co-treated with Melatonin] results in increased activity of CAT protein; [Melatonin co-treated with aluminum lactate] results in increased expression of CAT mRNA; [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein]; Melatonin inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]PMID:12500499 PMID:12823611 PMID:15589378 PMID:16098089 PMID:16931443 PMID:19539013 PMID:20556922 PMID:22013727 PMID:22526374 PMID:23374533 PMID:24318767 PMID:24733834 PMID:26286521 PMID:37348669 PMID:9194422
Catincreases activityISOCat (Mus musculus)6480464CTDMelatonin results in increased activity of CAT proteinPMID:23554006
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTD[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]PMID:19961921
Catmultiple interactionsISOCat (Mus musculus)6480464CTD[aluminum lactate co-treated with Melatonin] results in increased expression of CAT mRNA; [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CAT mRNA]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Urethane results in increased expression of CAT protein]PMID:16703270 PMID:17195641 PMID:19405147 PMID:19680607 PMID:23554006 PMID:28803342 PMID:29763682 PMID:31931096 PMID:37277016 PMID:37598416
Go Back to source page   Continue to Ontology report