GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | decreases cleavage | EXP | | 6480464 | CTD | Streptozocin results in decreased cleavage of CASP3 protein | PMID:23453443 | Casp3 | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of CASP3 mRNA; Streptozocin results in decreased expression of CASP3 protein | PMID:34455488 PMID:37081038 | Casp3 | increases activity | EXP | | 6480464 | CTD | Streptozocin results in increased activity of CASP3 protein | PMID:18758938 PMID:19133311 PMID:19682444 PMID:19840221 PMID:20053369 PMID:20224876 PMID:24333387 PMID:29606028 PMID:31029786 PMID:32805344 | Casp3 | increases cleavage | EXP | | 6480464 | CTD | Streptozocin results in increased cleavage of CASP3 protein | PMID:19931367 PMID:21599458 PMID:24810525 PMID:25541178 PMID:28856781 PMID:29606028 PMID:30980806 PMID:37431890 PMID:38049026 | Casp3 | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of CASP3 mRNA; Streptozocin results in increased expression of CASP3 protein; Streptozocin results in increased expression of CASP3 protein modified form | PMID:12502508 PMID:15976052 PMID:19951573 PMID:20654064 PMID:23267840 PMID:24333387 PMID:26614261 PMID:31323227 PMID:32246071 PMID:32710900 PMID:34455488 PMID:34661493 PMID:35414346 PMID:36504472 PMID:37352119 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of CASP3 protein; [Rolipram co-treated with Pentoxifylline] inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; [Streptozocin co-treated with Arsenic] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Cadmium] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with IGF2R protein modified form] results in increased expression of CASP3 protein modified form; [Streptozocin co-treated with Lead co-treated with Manganese co-treated with Cadmium co-treated with Arsenic] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Lead] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Manganese] results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; bisacurone inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; diallyl trisulfide inhibits the reaction [Streptozocin results in decreased cleavage of CASP3 protein]; Ellagic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Ellagic Acid promotes the reaction [sinapinic acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]]; ferulic acid analog inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of CASP3 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; Imatinib Mesylate inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]]; Memantine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; morin inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; nifuroxazide inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; nifuroxazide inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Ozone inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased expression of CASP3 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]; Propofol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Rivastigmine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Rolipram inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Rosiglitazone inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; sinapinic acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; sinapinic acid promotes the reaction [Ellagic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]]; Streptozocin results in increased expression of and results in increased cleavage of CASP3 protein; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Vitamin B 12 inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein] | PMID:18758938 PMID:19133311 PMID:19682444 PMID:19840221 PMID:19951573 PMID:20053369 PMID:21599458 PMID:23267840 PMID:23453443 PMID:24333387 PMID:24810525 PMID:25541178 PMID:26499206 PMID:26614261 PMID:28856781 PMID:29606028 PMID:30980806 PMID:31029786 PMID:31323227 PMID:32246071 PMID:32710900 PMID:32805344 PMID:34455488 PMID:34661493 PMID:35414346 PMID:36462176 PMID:36504472 PMID:36510688 PMID:37431890 PMID:38049026 | Casp3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Streptozocin analog results in increased activity of CASP3 protein; Streptozocin results in increased activity of CASP3 protein | PMID:18721751 PMID:20424226 | Casp3 | increases cleavage | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Streptozocin results in increased cleavage of CASP3 protein | PMID:24967692 PMID:26887929 PMID:29059224 PMID:29420703 PMID:34649470 | Casp3 | increases expression | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of CASP3 mRNA; Streptozocin results in increased expression of CASP3 protein modified form | PMID:27702591 PMID:29935216 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | [Streptozocin co-treated with bisphenol A] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] affects the cleavage of CASP3 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 protein; [Streptozocin co-treated with NQO1 protein mutant form] results in increased expression of CASP3 protein modified form; [Streptozocin co-treated with octylphenol] results in increased expression of CASP3 mRNA; fatostatin promotes the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; montelukast inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]; NTN1 protein inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; phillyrin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 protein]; Streptozocin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Streptozocin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CASP3 mRNA]; sulforaphane inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein] | PMID:20424226 PMID:23458895 PMID:24967692 PMID:25665769 PMID:26887929 PMID:27702591 PMID:29059224 PMID:29420703 PMID:29935216 PMID:33484791 PMID:34610774 PMID:34649470 | | ||||||||||||||||||||||
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