Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2275
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Casp3
Name:	caspase 3

Acc ID:	CHEBI:9009
Term:	Salidroside
Definition:	A glycoside that has formula C14H20O7.
Chemical ID:	MESH:C009172

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Casp3	multiple interactions	EXP		6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]; rhodioloside inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]	PMID:24072175 PMID:28465020 PMID:30991096
Casp3	multiple interactions	ISO	CASP3 (Homo sapiens)	6480464	CTD	rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; sirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]]	PMID:28851138

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