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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:8499
Term: propranolol
Definition: A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Chemical ID: MESH:D011433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3decreases expressionEXP 6480464CTDPropranolol results in decreased expression of CASP3 mRNAPMID:11218852
Casp3increases cleavageEXP 6480464CTDPropranolol results in increased cleavage of CASP3 proteinPMID:35738838
Casp3multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Propranolol results in increased cleavage of CASP3 protein]; Fat Emulsions, Intravenous inhibits the reaction [Propranolol results in increased cleavage of CASP3 protein]PMID:35738838
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDPropranolol results in increased activity of CASP3 proteinPMID:22700542
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDPropranolol results in increased cleavage of CASP3 proteinPMID:19106745
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDPalmitic Acid promotes the reaction [Propranolol results in increased activity of CASP3 protein]PMID:22700542
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