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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:78274
Term: ferruginol
Definition: An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.
Chemical ID: MESH:C431074
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDferruginol results in increased activity of CASP3 proteinPMID:30086653
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDpyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [ferruginol results in increased activity of CASP3 protein]PMID:30086653
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