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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:69093
Term: semilicoisoflavone B
Definition: A member of the class of 7-hydroxyisoflavones that is 2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one substituted by hydroxy groups at positions 5, 7 and 8'. It has been isolated from Glycyrrhiza uralensis.
Chemical ID: MESH:C554447
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDsemilicoisoflavone B results in increased cleavage of CASP3 proteinPMID:36901935
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDbenzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [semilicoisoflavone B results in increased cleavage of CASP3 protein]; BIRC5 protein inhibits the reaction [semilicoisoflavone B results in increased cleavage of CASP3 protein]PMID:36901935
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