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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:39214
Term: abamectin
Definition: Mixture of 80% avermectin B1a and 20% avermectin B1b.
Chemical ID: MESH:C048324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases expressionEXP 6480464CTDabamectin results in increased expression of CASP3 mRNA; abamectin results in increased expression of CASP3 proteinPMID:31739238 PMID:34748272
Casp3multiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CASP3 protein]PMID:31739238 PMID:34748272
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDabamectin results in increased activity of CASP3 proteinPMID:30958899
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