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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3increases activityISOCasp3 (Mus musculus)6480464CTDDextran Sulfate results in increased activity of CASP3 proteinPMID:27920257 PMID:28421826
Casp3increases cleavageISOCasp3 (Mus musculus)6480464CTDDextran Sulfate results in increased cleavage of CASP3 proteinPMID:21989142 PMID:27920257 PMID:31676321 PMID:37209277 PMID:38583725 PMID:38648921
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]; [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CASP3 mRNA; alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]; biochanin A inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]; daphnetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]; EIF2AK2 protein affects the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; gingerol inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]; Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]]; Plant Extracts inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]PMID:21989142 PMID:27920257 PMID:28421826 PMID:29950665 PMID:31676321 PMID:37209277 PMID:38648921
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