Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2275
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Casp3
Name:	caspase 3

Acc ID:	CHEBI:28918
Term:	(R)-adrenaline
Definition:	The R-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
Chemical ID:	MESH:D004837

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Casp3	increases activity	EXP		6480464	CTD	Epinephrine results in increased activity of CASP3 protein	PMID:19135123
Casp3	increases expression	EXP		6480464	CTD	Epinephrine results in increased expression of CASP3 protein	PMID:29233027
Casp3	multiple interactions	EXP		6480464	CTD	Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Tadalafil inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Vardenafil Dihydrochloride inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]	PMID:19135123 PMID:29233027
Casp3	increases activity	ISO	CASP3 (Homo sapiens)	6480464	CTD	Epinephrine results in increased activity of CASP3 protein	PMID:10728402
Casp3	multiple interactions	ISO	CASP3 (Homo sapiens)	6480464	CTD	Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]	PMID:10728402

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