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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:28584
Term: gossypol
Definition: A polyphenol that has formula C30H30O8.
Chemical ID: MESH:D006072
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTD[Gossypol co-treated with Methyltestosterone co-treated with Ethinyl Estradiol] results in increased expression of CASP3 mRNAPMID:15451339
Casp3increases activityISOCASP3 (Homo sapiens)6480464CTDGossypol results in increased activity of CASP3 proteinPMID:19825521
Casp3increases cleavageISOCASP3 (Homo sapiens)6480464CTDGossypol results in increased cleavage of CASP3 proteinPMID:18840529
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTD[zoledronic acid co-treated with Gossypol] results in increased activity of CASP3 proteinPMID:19825521
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