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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:10037
Term: wedelolactone
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.
Chemical ID: MESH:C051122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3multiple interactionsEXP 6480464CTDwedelolactone inhibits the reaction [Methamphetamine results in increased cleavage of and results in increased activity of CASP3 protein]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]PMID:25631491 PMID:29981346
Casp3multiple interactionsISOCasp3 (Mus musculus)6480464CTD2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [wedelolactone inhibits the reaction [Oxygen results in increased cleavage of CASP3 protein]]; wedelolactone inhibits the reaction [Oxygen results in increased cleavage of CASP3 protein]PMID:39110510
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