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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2261
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Camk2a
Name: calcium/calmodulin-dependent protein kinase II alpha
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Camk2adecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of CAMK2A mRNA; Streptozocin results in decreased expression of CAMK2A proteinPMID:24333387
Camk2amultiple interactionsEXP 6480464CTDIbuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]PMID:24333387
Camk2amultiple interactionsISOCamk2a (Mus musculus)6480464CTDmyristoylated autocamtide-2-related inhibitory peptide inhibits the reaction [Streptozocin results in increased phosphorylation of CAMK2A protein]; resveratrol inhibits the reaction [Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein]; Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A proteinPMID:20424226
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