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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca2
Name: BRCA2, DNA repair associated
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca2decreases expressionISOBrca2 (Mus musculus)6480464CTDDibutyl Phthalate results in decreased expression of BRCA2 mRNAPMID:17361019 PMID:21266533 PMID:31318015
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