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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmp4
Name: bone morphogenetic protein 4
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmp4increases expressionISOBMP4 (Homo sapiens)6480464CTDresveratrol results in increased expression of BMP4 mRNAPMID:25888808
Bmp4multiple interactionsISOBmp4 (Mus musculus)6480464CTDresveratrol inhibits the reaction [BMP4 protein results in increased expression of VEGFA mRNA]; resveratrol inhibits the reaction [BMP4 protein results in increased secretion of VEGFA protein]PMID:24435444
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