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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:80774
Term: tauroursodeoxycholic acid
Definition: A bile acid taurine conjugate derived from ursoodeoxycholic acid.
Chemical ID: MESH:C031655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDursodoxicoltaurine results in decreased expression of BAX proteinPMID:12721362
Baxincreases expressionEXP 6480464CTDursodoxicoltaurine results in increased expression of BAX proteinPMID:15255934
Baxmultiple interactionsEXP 6480464CTDursodoxicoltaurine inhibits the reaction [3-nitropropionic acid affects the localization of BAX protein]; ursodoxicoltaurine inhibits the reaction [Glutamic Acid results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]PMID:11080188 PMID:17881359 PMID:35028790
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDursodoxicoltaurine affects the localization of and results in decreased susceptibility to BAX protein; ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; ursodoxicoltaurine inhibits the reaction [APP gene mutant form results in increased expression of BAX protein]PMID:12627974 PMID:16923170
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