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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:63948
Term: trimethyltin
Definition: An organotin compound that consists of stannane in which three of the four hydrogens are substituted by methyl groups.
Chemical ID: MESH:C046488
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDtrimethyltin results in increased expression of BAX proteinPMID:26756313
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; magnolol inhibits the reaction [trimethyltin results in increased expression of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]PMID:25895139 PMID:26756313
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