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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:5834
Term: hyperforin
Definition: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.
Chemical ID: MESH:C001654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDhyperforin results in decreased expression of BAX mRNAPMID:30481499
Baxmultiple interactionsEXP 6480464CTDhyperforin inhibits the reaction [aluminum maltolate results in increased expression of BAX mRNA]PMID:30481499
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDhyperforin results in increased expression of BAX proteinPMID:32485087
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDhyperforin inhibits the reaction [aluminum maltolate results in increased expression of BAX mRNA]PMID:30481499
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