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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDEmodin results in decreased expression of BAX proteinPMID:19549930
Baxincreases expressionEXP 6480464CTDEmodin results in increased expression of BAX proteinPMID:35753641
Baxmultiple interactionsEXP 6480464CTD2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside promotes the reaction [Emodin results in increased expression of BAX protein]PMID:35753641
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDEmodin affects the expression of BAX proteinPMID:27032576
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]PMID:27032576
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