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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDalpha-Tocopherol results in increased expression of BAX mRNAPMID:26332274
Baxmultiple interactionsEXP 6480464CTDalpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]PMID:32134168 PMID:38242491
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDalpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]PMID:11805214 PMID:36058301
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