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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:131923
Term: salubrinal
Definition: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Chemical ID: MESH:C496827
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDsalubrinal inhibits the reaction [Acrylamide results in increased expression of BAX protein]; salubrinal inhibits the reaction [cadmium acetate results in increased expression of BAX protein]PMID:30605698 PMID:38604440
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]; salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]PMID:21616140
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