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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2150
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arg1
Name: arginase 1
Acc ID: CHEBI:231613
Term: AM6545
Definition: AM6545 is a CB1 antagonist
Chemical ID: MESH:C551825
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arg1multiple interactionsISOArg1 (Mus musculus)6480464CTDAM6545 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone affects the expression of ARG1 mRNA]; AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]; Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]]PMID:30184259
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