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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:34025
Term: 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Definition: A bisphenol that has formula C14H11Cl3O2.
Chemical ID: MESH:C404910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to AR proteinPMID:14565775
Ardecreases activityISOAR (Homo sapiens)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased activity of AR proteinPMID:11861975
Ardecreases expressionISOAr (Mus musculus)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of AR mRNAPMID:11509743
Armultiple interactionsISOAr (Mus musculus)6480464CTD[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of AR mRNAPMID:11509743
Armultiple interactionsISOAR (Homo sapiens)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane binds to and results in decreased activity of AR protein; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Estradiol results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]PMID:10999957 PMID:11861976 PMID:15026081 PMID:15483189 PMID:15589981 PMID:15840436 PMID:28009930 PMID:33049310 PMID:9705896
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