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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2143
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp4
Name: aquaporin 4
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp4affects expressionISOAqp4 (Mus musculus)6480464CTDPhenobarbital affects the expression of AQP4 mRNAPMID:23091169
Aqp4multiple interactionsISOAqp4 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AQP4 mRNAPMID:24535843
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