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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:566274
Term: malonaldehyde
Definition: A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.
Chemical ID: MESH:D008315
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases metabolic processingISOAldh1a1 (Mus musculus)6480464CTDALDH1A1 protein results in increased metabolism of MalondialdehydePMID:21256123
Aldh1a1increases oxidationISOALDH1A1 (Homo sapiens)6480464CTDALDH1A1 protein results in increased oxidation of MalondialdehydePMID:22339434
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