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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1decreases expressionEXP 6480464CTDtitanium dioxide results in decreased expression of ALDH1A1 mRNAPMID:30012374
Aldh1a1decreases expressionISOAldh1a1 (Mus musculus)6480464CTDtitanium dioxide results in decreased expression of ALDH1A1 mRNAPMID:23557971 PMID:27760801
Aldh1a1increases phosphorylationISOALDH1A1 (Homo sapiens)6480464CTDtitanium dioxide results in increased phosphorylation of ALDH1A1 proteinPMID:21439344
Aldh1a1multiple interactionsISOAldh1a1 (Mus musculus)6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ALDH1A1 mRNAPMID:29950665
Aldh1a1multiple interactionsISOALDH1A1 (Homo sapiens)6480464CTD[Vitallium analog binds to titanium dioxide] which results in decreased expression of ALDH1A1 mRNAPMID:23825117
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