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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:17153
Term: propanal
Definition: An aldehyde that consists of ethane bearing a formyl substituent. The parent of the class of propanals.
Chemical ID: MESH:C005556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases oxidationEXP 6480464CTDALDH1A1 protein results in increased oxidation of propionaldehydePMID:10998257
Aldh1a1increases metabolic processingISOAldh1a1 (Mus musculus)6480464CTDALDH1A1 protein results in increased metabolism of propionaldehydePMID:21256123
Aldh1a1increases oxidationISOALDH1A1 (Homo sapiens)6480464CTDALDH1A1 protein results in increased oxidation of propionaldehydePMID:21349255
Aldh1a1multiple interactionsISOALDH1A1 (Homo sapiens)6480464CTD[ALDH1A1 protein binds to NAD] which results in increased oxidation of propionaldehyde; [ALDH1A1 protein co-treated with NAD] results in increased oxidation of propionaldehyde; [NAD co-treated with propionaldehyde] inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]; propionaldehyde inhibits the reaction [Acrolein results in decreased activity of ALDH1A1 protein]PMID:10559215 PMID:10856427 PMID:22339434 PMID:25450233
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