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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alad
Name: aminolevulinate dehydratase
Acc ID: CHEBI:77543
Term: ebselen
Definition: A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Chemical ID: MESH:C042986
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aladdecreases activityEXP 6480464CTDebselen results in decreased activity of ALAD proteinPMID:14630126 PMID:23933410
Aladmultiple interactionsEXP 6480464CTDDithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]PMID:23933410
Aladmultiple interactionsISOAlad (Mus musculus)6480464CTDebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]PMID:17624921
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