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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDTriclosan results in decreased phosphorylation of AKT1 proteinPMID:31381933
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDTriclosan results in decreased phosphorylation of AKT1 proteinPMID:28973666
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTD[rosiglitazone results in increased activity of PPARG protein] inhibits the reaction [Triclosan results in decreased phosphorylation of AKT1 protein]PMID:28973666
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