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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agt
Name: angiotensinogen
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of AGT protein; Doxorubicin results in increased expression of AGT protein modified formPMID:10515446 PMID:17061561 PMID:18215452
Agtmultiple interactionsEXP 6480464CTDbenazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; wulingsan inhibits the reaction [Doxorubicin results in increased expression of AGT protein]PMID:10515446 PMID:17061561 PMID:18215452
Agtincreases expressionISOAGT (Homo sapiens)6480464CTDDoxorubicin results in increased expression of AGT mRNAPMID:29803840
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