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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2055
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra1a
Name: adrenoceptor alpha 1A
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra1aaffects bindingISOADRA1A (Homo sapiens)6480464CTDVerapamil binds to ADRA1A proteinPMID:9570190
Adra1amultiple interactionsISOADRA1A (Homo sapiens)6480464CTD[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]PMID:9570190
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