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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2055
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adra1a
Name: adrenoceptor alpha 1A
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adra1aaffects expressionEXP 6480464CTDNorepinephrine affects the expression of ADRA1A proteinPMID:12417256
Adra1aaffects response to substanceEXP 6480464CTDADRA1A protein affects the susceptibility to NorepinephrinePMID:12417256
Adra1aincreases activityEXP 6480464CTDNorepinephrine results in increased activity of ADRA1A proteinPMID:10416824
Adra1amultiple interactionsEXP 6480464CTD5-methylurapidil inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; BMY 7378 inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; chlorethylclonidine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Spiperone inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]PMID:10416824
Adra1aaffects bindingISOADRA1A (Homo sapiens)6480464CTDNorepinephrine binds to ADRA1A proteinPMID:8183249
Adra1amultiple interactionsISOADRA1A (Homo sapiens)6480464CTD[Norepinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1A protein; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]PMID:20030735
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