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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:9180
Term: Sodium salicylate
Definition: An organic molecular entity that has formula C7H5O3.Na.
Chemical ID: MESH:D012980
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDSodium Salicylate results in increased cleavage of PARP1 proteinPMID:10090950 PMID:9694730
Parp1increases expressionISOPARP1 (Homo sapiens)6480464CTDSodium Salicylate results in increased expression of PARP1 mRNAPMID:29117515
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDSodium Salicylate inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]PMID:29117515
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