GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | increases expression | EXP | | 6480464 | CTD | Sirolimus results in increased expression of PARP1 protein modified form | PMID:26825372 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | [Sirolimus co-treated with Resveratrol] results in increased cleavage of PARP1 protein; Sirolimus inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; TSC2 protein inhibits the reaction [[Sirolimus co-treated with Resveratrol] results in increased cleavage of PARP1 protein] | PMID:24304514 PMID:34374793 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Sirolimus results in increased cleavage of PARP1 protein | PMID:25307878 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [Sirolimus co-treated with ovatodiolide] results in increased cleavage of PARP1 protein; ATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Sirolimus inhibits the reaction [Ethanol results in increased cleavage of PARP1 protein]; Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [ovatodiolide results in increased cleavage of PARP1 protein] | PMID:19682553 PMID:21410490 PMID:32802178 PMID:33002460 PMID:38000454 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Sirolimus promotes the reaction [Cadmium results in increased cleavage of PARP1 protein] | PMID:29111403 | | ||||||||||||||||||||||
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