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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:4357
Term: deguelin
Definition: A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.
Chemical ID: MESH:C107676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDdeguelin results in increased cleavage of PARP1 proteinPMID:17035597 PMID:22986522
Parp1increases expressionISOPARP1 (Homo sapiens)6480464CTDdeguelin metabolite results in increased expression of PARP1 protein modified form; deguelin results in increased expression of PARP1 protein modified formPMID:19139008
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]PMID:17015749 PMID:25242579
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