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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:41977
Term: daunorubicin
Definition: A natural product found in Actinomadura roseola.
Chemical ID: MESH:D003630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects expressionISOPARP1 (Homo sapiens)6480464CTDDaunorubicin affects the expression of PARP1 mRNAPMID:27780733
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDDaunorubicin results in increased cleavage of PARP1 proteinPMID:10766178 PMID:11082532 PMID:34963561
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[Daunorubicin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 proteinPMID:12780785
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