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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:41941
Term: (3,4-dihydroxyphenyl)acetic acid
Definition: A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
Chemical ID: MESH:D015102
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTD[PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of 3,4-Dihydroxyphenylacetic AcidPMID:10318960
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