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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1multiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of PARP1 mRNAPMID:25729387
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDoxaliplatin results in increased cleavage of PARP1 proteinPMID:16243822
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of PARP1 protein; [S100A11 mutant form results in increased susceptibility to oxaliplatin] which results in increased cleavage of PARP1 protein; gefitinib affects the reaction [oxaliplatin results in increased cleavage of PARP1 protein]PMID:16243822 PMID:19728331 PMID:25940438
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