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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects response to substanceISOParp1 (Mus musculus)6480464CTDPARP1 protein affects the susceptibility to Vitamin K 3PMID:21124846
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[sodium arsenite co-treated with Vitamin K 3] results in increased cleavage of PARP1 proteinPMID:19082730
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