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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:28863
Term: flavanones
Definition: Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.
Chemical ID: MESH:D044950
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDFlavanones results in increased cleavage of PARP1 proteinPMID:21616090
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Flavanones results in increased cleavage of PARP1 protein]; U 0126 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]PMID:21616090
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