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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2004
Species: Rattus norvegicus
RGD Object: Gene
Symbol: A2m
Name: alpha-2-macroglobulin
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
A2mincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of A2M mRNA; Cadmium Chloride results in increased expression of A2M proteinPMID:15618353 PMID:25993096
A2mmultiple interactionsEXP 6480464CTDApigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]; N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein]PMID:15618353
A2mmultiple interactionsISOA2M (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of A2M mRNAPMID:36602393
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