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GENE - TERM ANNOTATION REPORT

RGD ID: 18909113
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Oprm1
Name: opioid receptor mu 1
Acc ID: DOID:9976
Term: heroin dependence
Definition: An opiate dependence that involves the continued use of heroin despite problems related to use of the substance. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Opioid_dependence "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprm1 ISOOPRM1 (Homo sapiens)9068941RGDDNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)PMID:28976288 REF_RGD_ID:401831044
Oprm1 ISOOPRM1 (Homo sapiens)9068941RGDDNA:SNP, haplotype: :rs483481 (human)PMID:32189578 REF_RGD_ID:401827950
Oprm1 ISOOPRM1 (Homo sapiens)9068941RGDmRNA:splice variants:prefrontal cortexPMID:32506472 REF_RGD_ID:401831047
Oprm1no_associationISOOPRM1 (Homo sapiens)9068941RGDDNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)PMID:11424981 REF_RGD_ID:401827953
Oprm1severityISOOPRM1 (Homo sapiens)9068941RGDDNA:SNPs, haplotypes: :rs696522, rs1381376, rs3778151 (human)PMID:17157823 REF_RGD_ID:401827940
Oprm1susceptibilityISOOPRM1 (Homo sapiens)9068941RGDDNA:SNPs, haplotypes: :multiplePMID:28692418 REF_RGD_ID:401831045
Oprm1 ISOOPRM1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:20201854
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