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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624098
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b9increases expressionEXP 6480464CTDStreptozocin results in increased expression of CYP2B9 mRNAPMID:22342832
Cyp2b9multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of CYP2B9 mRNA; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]; Metformin promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]PMID:22342832 PMID:29127188
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