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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617628
Species: Mus musculus
RGD Object: Gene
Symbol: Hars1
Name: histidyl-tRNA synthetase 1
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hars1decreases expressionISOHars1 (Rattus norvegicus)6480464CTDOxaliplatin results in decreased expression of HARS1 mRNAPMID:25729387
Hars1multiple interactionsISOHars1 (Rattus norvegicus)6480464CTD[Oxaliplatin co-treated with Topotecan] results in decreased expression of HARS1 mRNAPMID:25729387
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