GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fasn | decreases expression | EXP | | 6480464 | CTD | Methionine deficiency results in decreased expression of FASN mRNA | PMID:25178843 | Fasn | multiple interactions | EXP | | 6480464 | CTD | 5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN mRNA]; 5-(3-methoxy-5-(4-methoxystyryl)phenoxy)-2,2-dimethylpentanoic acid analog inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]; [Choline deficiency co-treated with Methionine deficiency] results in decreased expression of FASN mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of FASN mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of FASN mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FASN gene; [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FASN mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein; alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]; Chenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]; Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of FASN mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol A 24-acetate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FASN protein]] | PMID:20938992 PMID:23038002 PMID:25178843 PMID:27773935 PMID:28163111 PMID:30745416 PMID:31678261 | Fasn | multiple interactions | ISO | Fasn (Rattus norvegicus) | 6480464 | CTD | [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FASN mRNA; geraniol promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FASN mRNA] | PMID:26695085 | | ||||||||||||||||||||||
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