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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614799
Species: Mus musculus
RGD Object: Gene
Symbol: Slc47a2
Name: solute carrier family 47, member 2
Acc ID: CHEBI:8455
Term: proguanil
Definition: A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Chemical ID: MESH:D002727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc47a2multiple interactionsISOSLC47A2 (Homo sapiens)6480464CTDProguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]PMID:22419765
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