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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:proguanil
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Accession:CHEBI:8455 term browser browse the term
Definition:A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Synonyms:exact_synonym: N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
 related_synonym: 1-(p-chlorophenyl)-5-isopropylbiguanide;   Chlorguanide;   Chloroguanide;   Formula=C11H16ClN5;   InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17);   InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N;   N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide;   SMILES=CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1;   proguanilum
 xref: Beilstein:2811599;   CAS:500-92-5;   DrugBank:DB01131;   Drug_Central:2282;   HMDB:HMDB0015263;   KEGG:C07631;   KEGG:D08428;   LINCS:LSM-2618
 xref_mesh: MESH:D002727
 xref: PMID:10348748;   PMID:10848923;   PMID:15504827;   PMID:8866915;   Reaxys:2811599;   Wikipedia:Proguanil



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proguanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing
decreases activity
ISO CYP2C19 protein results in increased metabolism of Proguanil
Proguanil results in decreased activity of CYP2C19 protein
CTD PMID:11124226 PMID:12464242 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461
JBrowse link
G Slc47a1 solute carrier family 47, member 1 multiple interactions ISO Proguanil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Proguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,192,453...61,233,686
Ensembl chr11:61,192,457...61,233,686
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      biological role 22172
        antimicrobial agent 19574
          antimicrobial drug 9894
            antiprotozoal drug 7451
              proguanil 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic molecule 21654
                              organic cyclic compound 21259
                                carbocyclic compound 19665
                                  benzenoid aromatic compound 18767
                                    benzenes 18558
                                      chlorobenzenes 15446
                                        monochlorobenzenes 12085
                                          proguanil 4
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