GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | FASLG | increases expression | ISO | Fasl (Mus musculus) | 6480464 | CTD | triptolide results in increased expression of FASL mRNA; triptolide results in increased expression of FASL protein | PMID:24949944 PMID:26990902 | FASLG | multiple interactions | ISO | Fasl (Mus musculus) | 6480464 | CTD | [triptolide co-treated with FASL protein] results in decreased expression of MIR137; [triptolide co-treated with FASL protein] results in decreased expression of XIAP mRNA; [triptolide co-treated with FASL protein] results in decreased expression of XIAP protein; [triptolide co-treated with FASL protein] results in increased expression of ALPL protein; [triptolide co-treated with FASL protein] results in increased expression of GOT1 protein; [triptolide co-treated with FASL protein] results in increased expression of GPT protein; [triptolide co-treated with FASL protein] results in increased expression of MIR137; [triptolide co-treated with FASL protein] results in increased expression of XIAP mRNA; CASP3 inhibits the reaction [[triptolide co-treated with FASL protein] results in increased cleavage of XIAP protein]; FASL protein promotes the reaction [triptolide results in decreased expression of BCL2 protein]; FASL protein promotes the reaction [triptolide results in decreased expression of FLIP protein]; FASL protein promotes the reaction [triptolide results in increased cleavage of and results in increased activity of CASP3 protein]; IL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]; MIR137 promotes the reaction [[triptolide co-treated with FASL protein] results in decreased expression of XIAP protein] | PMID:24949944 PMID:37944651 | | ||||||||||||||||||||||
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