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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atm
Name: ATM serine/threonine kinase
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmincreases phosphorylationISOAtm (Mus musculus)6480464CTDsodium arsenite results in increased phosphorylation of ATM proteinPMID:18996350
Atmincreases response to substanceISOATM (Homo sapiens)6480464CTDATM gene mutant form results in increased susceptibility to sodium arsenitePMID:11507245
Atmmultiple interactionsISOAtm (Mus musculus)6480464CTDATM protein affects the reaction [sodium arsenite results in decreased expression of HSP90AB1 mRNA]; ATM protein affects the reaction [sodium arsenite results in increased phosphorylation of TRP53 protein]PMID:18996350
Atmmultiple interactionsISOATM (Homo sapiens)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of ATM mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of and results in decreased phosphorylation of ATM protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ATM mRNA; ATM gene mutant form inhibits the reaction [sodium arsenite results in increased expression of CDKN1A protein]; ATM gene mutant form inhibits the reaction [sodium arsenite results in increased expression of TP53 protein]PMID:11507245 PMID:35513056 PMID:39836092
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