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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589743
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ulk1
Name: unc-51 like autophagy activating kinase 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ulk1affects phosphorylationEXP 6480464CTDParaquat affects the phosphorylation of ULK1 proteinPMID:27324791
Ulk1affects response to substanceEXP 6480464CTDULK1 protein affects the susceptibility to ParaquatPMID:27324791
Ulk1decreases expressionEXP 6480464CTDParaquat results in decreased expression of ULK1 mRNAPMID:32680482
Ulk1decreases phosphorylationISOUlk1 (Mus musculus)6480464CTDParaquat results in decreased phosphorylation of ULK1 proteinPMID:25092649 PMID:27246695
Ulk1increases phosphorylationISOUlk1 (Mus musculus)6480464CTDParaquat results in increased phosphorylation of ULK1 proteinPMID:25092649
Ulk1multiple interactionsISOUlk1 (Mus musculus)6480464CTDTLR4 protein affects the reaction [Paraquat results in decreased phosphorylation of ULK1 protein]PMID:27246695
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